Biography
In his research, Corvera focuses on the mechanisms that underlie inflammation, thickening and scarring in the biliary tract.
Corvera graduated from the University of California, San Diego School of Medicine. He completed a residency in general surgery at UCSF. At Memorial Sloan Kettering Cancer Center in New York City, he completed a clinical fellowship in surgical oncology as well as a fellowship in hepatobiliary surgery.
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Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Memorial Sloan Kettering Cancer Center, New York | Hepatobiliary Surgery | Surgery | 2002 |
Memorial Sloan Kettering Cancer Center , New York | Surgical Oncology Clinical Fellowship | Surgery | 2001 |
University of California, San Francisco | General Surgery Residency | School of Medicine | 2000 |
University of California San Diego | M.D. | School of Medicine | 1993 |
Board Certifications
- American Board of Surgery
Clinical Expertise
Ascites
Bile Duct Injuries
Bile Duct Strictures
Bile Duct Cancer (Cholangiocarcinoma)
Gastrointestinal Carcinoid Tumor
Gastrointestinal Stromal Tumor (GIST)
Choledochal Cysts
Portal Hypertension
Liver Cancer (Hepatocellular Carcinoma)
Minimally Invasive Liver & Pancreas Surgery
Melanoma
Pancreatic Cancer
Pancreatic Cysts
Soft Tissue Sarcomas
Liver Cysts
Liver Metastases
Gallbladder Cancer
Stomach (Gastric) Cancer
Pancreatic Neuroendocrine (Islet Cell) Tumors
Bridging Therapies to Downstage HCC in Setting of Liver Transplantation
Program Affiliations
Hepatobiliary and Pancreas Surgery Program
UCSF Helen Diller Family Comprehensive Cancer Center
UCSF Department of Surgery at the San Francisco VA
In the News
Research Narrative
Dr. Corvera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation. More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation. Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr.Corvera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.
Research Interests
Proteases and Proteinase Activated Receptors in the Biliary Tract
Publications
- Impact of pre-operative positron emission tomography in gallbladder cancer.| | PubMed
- Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.| | PubMed
- The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.| | PubMed
- The TGR5 receptor mediates bile acid-induced itch and analgesia.| | PubMed
- Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.| | PubMed
- The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.| | PubMed
- Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.| | PubMed
- Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity.| | PubMed
- Visual vignette. What is the diagnosis? Insulin-secreting tumor.| | PubMed
- Laparoscopic treatment of liver tumours using a two-needle probe bipolar radiofrequency ablation device.| | PubMed