University of California San Francisco

Claus Niemann - 144
Claus
Niemann
MD

Professor of Anesthesia and Surgery
Department of Anesthesia & Perioperative Care
Department of Surgery
Co-Director, Ischemic Organ Injury Lab

Biography

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury.

Education

Education
  • 1986-93, Ludwig-Maximilians University, Munich, Germany, M.D.
Residencies
  • 1993-94  Intern ;  City Hospital St. Georg,, University of Hamburg, Germany and Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
  • 1996-99, University of California, San Francisco, Resident, Anesthesia
Postdoctoral Training
  • 1994-96, Department of Anesthesiology, Northwestern University, Chicago, Illinois, Fellow, Postdoctoral Research

Board Certifications

  • American Board of Anesthesiology

Clinical Expertise

Pancreas Transplantation

Liver Transplantation

Kidney Transplantation

Clinical Trials

  1. Intensive Insulin Therapy in Deceased Donors (NCT01140035)
    Related Conditions: Kidney Transplant, Transplants| Start Date: | End Date:

Program Affiliations

  • Department of Anesthesia and Perioperative Care
  • Department of Surgery, Division of Transplantation
  • UCSF Liver Center

Research Narrative

My group is interested in identifying why obese individuals are at greater risk of liver injury in the setting of trauma or surgery. My long-term goal is to understand the relationship between metabolic and immunologic processes in the liver. One potential link between these underlying mechanisms could be the peptide leptin, which can profoundly modify inflammatory and metabolic pathways. The goal of this research effort is to improve understanding of the impact of leptin on acute inflammatory cascade and metabolic response during hepatic ischemia-reperfusion. This will benefit patients by improving risk-stratification of candidates for hepatic surgery and possibly lead to preventive therapies for ischemia-reperfusion injury. 

Research Interests

Inflammatory response to injuryIschemia reperfusion injury

Liver transplantation

Metabolomics

Organ donation

Renal and hepatic injury during surgery

Intensive Insulin Therapy in Deceased Donors-to improve renal allograft function and transplanted allograft outcomes

View Research Profile at UCSF Clinical & Translational Science Institute

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 121
  1. Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients.
    Niemann CU, Yost CS, Mandell S, Henthorn TK| | PubMed
  2. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
    Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U| | PubMed
  3. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
    Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U| | PubMed
  4. Isoflurane alters the recirculatory pharmacokinetics of physiologic markers.
    Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK| | PubMed
  5. Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol.
    Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ| | PubMed
  6. Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective.
    Henthorn TK, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ| | PubMed
  7. Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water.
    Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ| | PubMed
  8. The effect of halothane on the recirculatory pharmacokinetics of physiologic markers.
    Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK| | PubMed
  9. A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs.
    Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK| | PubMed
  10. Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs.
    Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, Henthorn TK| | PubMed
121
View all 121 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 121
  1. Therapeutic Hypothermia in Low-Risk Nonpumped Brain-Dead Kidney Donors: A Randomized Clinical Trial.
    Patel MS, Salcedo-Betancourt JD, Saunders C, Broglio K, Malinoski D, Niemann CU| | PubMed
  2. International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World.
    Rodriguez-Davalos MI, Lopez-Verdugo F, Kasahara M, Muiesan P, Reddy MS, Flores-Huidobro Martinez A, Xia Q, Hong JC, Niemann CU, Seda-Neto J, Miloh TA, Yi NJ, Mazariegos GV, Ng VL, Esquivel CO, Lerut J, Rela M, Pediatric Liver Transplantation Global Census Group| | PubMed
  3. Lactate concentration at the end of liver transplant: Early predictor of graft function or just one piece of the puzzle?
    Galli AM, Kothari R, Adelmann D, Holm Z, Bokoch MP, De Gasperi A, Niemann CU, Kolodzie K| | PubMed
  4. Hypothermia or Machine Perfusion in Kidney Donors.
    Malinoski D, Saunders C, Swain S, Groat T, Wood PR, Reese J, Nelson R, Prinz J, Kishish K, Van De Walker C, Geraghty PJ, Broglio K, Niemann CU| | PubMed
  5. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference.
    Pollok JM, Tinguely P, Berenguer M, Niemann CU, Raptis DA, Spiro M, ERAS4OLT.org collaborative| | PubMed
  6. Perioperative mortality in liver transplantation before and after the implementation of the organ allocation policy Share 35.
    Holm ZD, Kolodzie K, Galli AM, Meyhoff CS, Niemann CU, Adelmann D| | PubMed
  7. Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.
    Meier RPH, Kelly Y, Yamaguchi S, Braun HJ, Lunow-Luke T, Adelmann D, Niemann C, Maluf DG, Dietch ZC, Stock PG, Kang SM, Feng S, Posselt AM, Gardner JM, Syed SM, Hirose R, Freise CE, Ascher NL, Roberts JP, Roll GR| | PubMed
  8. Expedited evaluation for liver transplantation: A critical look at processes and outcomes.
    Braun HJ, Mello A, Kothari R, Ku E, Yilma M, Tavakol M, Zhang L, Niemann CU, Ascher NL, Adelmann D| | PubMed
  9. Organ donor management goals and delayed graft function in adult kidney transplant recipients.
    Kothari R, Tolles J, Adelmann D, Lewis RJ, Malinoski DJ, Niemann CU| | PubMed
  10. Perioperative Normal Saline Administration and Delayed Graft Function in Patients Undergoing Kidney Transplantation: A Retrospective Cohort Study.
    Kolodzie K, Cakmakkaya OS, Boparai ES, Tavakol M, Feiner JR, Kim MO, Newman TB, Niemann CU| | PubMed
  11. Machine Learning Prediction of Liver Allograft Utilization From Deceased Organ Donors Using the National Donor Management Goals Registry.
    Bishara AM, Lituiev DS, Adelmann D, Kothari RP, Malinoski DJ, Nudel JD, Sally MB, Hirose R, Hadley DD, Niemann CU| | PubMed
  12. Enhanced recovery after surgery programs improve short-term outcomes after liver transplantation-A systematic review and meta-analysis.
    Tinguely P, Morare N, Ramirez-Del Val A, Berenguer M, Niemann CU, Pollok JM, Raptis DA, Spiro M| | PubMed
  13. Assessment of the global practice of living donor liver transplantation.
    Emamaullee J, Conrad C, Kim M, Goldbeck C, Kwon Y, Singh P, Niemann CU, Sher L, Genyk Y| | PubMed
  14. Raster Thomson scattering in large-scale laser plasmas produced at high repetition rate.
    Kaloyan M, Ghazaryan S, Constantin CG, Dorst RS, Heuer PV, Pilgram JJ, Schaeffer DB, Niemann C| | PubMed
  15. Critical care and ventilatory management of deceased organ donors impact lung use and recipient graft survival.
    Swanson EA, Patel MS, Hutchens MP, Niemann CU, Groat T, Malinoski DJ, Sally MB| | PubMed
  16. Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues.
    Yang F, Nielsen SCA, Hoh RA, Röltgen K, Wirz OF, Haraguchi E, Jean GH, Lee JY, Pham TD, Jackson KJL, Roskin KM, Liu Y, Nguyen K, Ohgami RS, Osborne EM, Nadeau KC, Niemann CU, Parsonnet J, Boyd SD| | PubMed
  17. Prospective Multicenter Study of Early Antiviral Therapy in Liver and Kidney Transplant Recipients of HCV-Viremic Donors.
    Terrault NA, Burton J, Ghobrial M, Verna E, Bayer J, Klein C, Victor D, Mohan S, Trotter J, Dodge J, Niemann CU, Rubin RA| | PubMed
  18. Weighing the waitlist: Weight changes and access to kidney transplantation among obese candidates.
    Ku E, Whelan AM, McCulloch CE, Lee B, Niemann CU, Roll GR, Grimes BA, Johansen KL| | PubMed
  19. COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.
    Syed SM, Gardner J, Roll G, Webber A, Mehta N, Shoji J, Adelmann D, Niemann C, Braun HJ, Mello A, Yao F, Posselt A, Kang SM, Hirose R, Roberts J, Feng S, Ascher N, Stock P, Freise C| | PubMed
  20. The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.
    Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D| | PubMed
  21. Measurements of ion velocity distributions in a large scale laser-produced plasma.
    Dorst RS, Heuer PV, Schaeffer DB, Constantin CG, Niemann C| | PubMed
  22. Longer Distance From Dialysis Facility to Transplant Center Is Associated With Lower Access to Kidney Transplantation.
    Whelan AM, Johansen KL, McCulloch CE, Adelmann D, Niemann CU, Roll GR, Siyahian S, Grimes B, Ku E| | PubMed
  23. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
    Iske J, Seyda M, Heinbokel T, Maenosono R, Minami K, Nian Y, Quante M, Falk CS, Azuma H, Martin F, Passos JF, Niemann CU, Tchkonia T, Kirkland JL, Elkhal A, Tullius SG| | PubMed
  24. Impact of Deceased Donor Management on Donor Heart Use and Recipient Graft Survival.
    Swanson EA, Adams T, Patel MS, De La Cruz S, Hutchens M, Khush K, Sally MB, Niemann CU, Groat T, Malinoski DJ| | PubMed
  25. Bacchus Listed for a Liver Transplant: Comment.
    Niemann CU| | PubMed
  26. Vasopressor selection during critical care management of brain dead organ donors and the effects on kidney graft function.
    Swanson EA, Patel MS, Groat T, Jameson NE, Ellis MKM, Hutchens MP, Niemann CU, Malinoski DJ, Sally MB| | PubMed
  27. The role of deceased donor liver biopsy: An analysis of 5449 liver transplant recipients.
    Patel MS, Mohebali J, Coe TM, Sally M, Groat T, Niemann CU, Malinoski DJ, Vagefi PA| | PubMed
  28. Transplant anesthesia and critical care: Current research and possible future developments.
    Niemann CU, Biancofiore G| | PubMed
  29. Therapeutic Hypothermia in Organ Donors: Follow-up and Safety Analysis.
    Malinoski D, Patel MS, Axelrod DA, Broglio K, Lewis RJ, Groat T, Niemann CU| | PubMed
  30. Modeling the economic benefit of targeted mild hypothermia in deceased donor kidney transplantation.
    Axelrod DA, Malinoski D, Patel MS, Broglio K, Lewis R, Groat T, Lentine KL, Schnitzler M, Niemann CU| | PubMed
  31. The Continued Need for Clinical Trials in Deceased Organ Donor Management.
    Niemann CU, Matthay MA, Ware LB| | PubMed
  32. Deceased organ donor factors influencing pancreatic graft transplantation and survival.
    Sally MB, Ellis MK, Hutchens M, Groat T, Swanson E, Patel MS, Niemann CU, Malinoski DJ| | PubMed
  33. The Impact of Deceased Donor Liver Extraction Time on Early Allograft Function in Adult Liver Transplant Recipients.
    Adelmann D, Roll GR, Kothari R, Syed S, Burdine LJ, Tavakol M, Niemann CU| | PubMed
  34. Intraoperative Management of Liver Transplant Patients Without the Routine Use of Renal Replacement Therapy.
    Adelmann D, Olmos A, Liu LL, Feiner JR, Roll GR, Burdine L, Tavakol M, Syed S, Orandi BJ, Niemann CU| | PubMed
  35. Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis.
    Adelmann D, Bicknell L, Niemann CU, Feiner J, Roll GR, Burdine L, Whitlock EL| | PubMed
  36. Organ Donor Management: Part 1. Toward a Consensus to Guide Anesthesia Services During Donation After Brain Death.
    Souter MJ, Eidbo E, Findlay JY, Lebovitz DJ, Moguilevitch M, Neidlinger NA, Wagener G, Paramesh AS, Niemann CU, Roberts PR, Pretto EA| | PubMed
  37. Comments on "Impact of spontaneous donor hypothermia on graft outcomes after kidney transplantation".
    Niemann CU, Broglio K, Malinoski D| | PubMed
  38. Potentially inappropriate liver transplantation in the era of the "sickest first" policy - A search for the upper limits.
    Linecker M, Krones T, Berg T, Niemann CU, Steadman RH, Dutkowski P, Clavien PA, Busuttil RW, Truog RD, Petrowsky H| | PubMed
  39. Protecting the Kidney in Liver Transplant Recipients: Practice-Based Recommendations From the American Society of Transplantation Liver and Intestine Community of Practice.
    Levitsky J, O'Leary JG, Asrani S, Sharma P, Fung J, Wiseman A, Niemann CU| | PubMed
  40. Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function.
    Niemann CU, Malinoski D| | PubMed
  41. Impact of a quality improvement project on deceased organ donor management.
    Olmos A, Feiner J, Hirose R, Swain S, Blasi A, Roberts JP, Niemann CU| | PubMed
  42. Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function.
    Niemann CU, Feiner J, Swain S, Bunting S, Friedman M, Crutchfield M, Broglio K, Hirose R, Roberts JP, Malinoski D| | PubMed
  43. Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement.
    Kotloff RM, Blosser S, Fulda GJ, Malinoski D, Ahya VN, Angel L, Byrnes MC, DeVita MA, Grissom TE, Halpern SD, Nakagawa TA, Stock PG, Sudan DL, Wood KE, Anillo SJ, Bleck TP, Eidbo EE, Fowler RA, Glazier AK, Gries C, Hasz R, Herr D, Khan A, Landsberg D, Lebovitz DJ, Levine DJ, Mathur M, Naik P, Niemann CU, Nunley DR, O'Connor KJ, Pelletier SJ, Rahman O, Ranjan D, Salim A, Sawyer RG, Shafer T, Sonneti D, Spiro P, Valapour M, Vikraman-Sushama D, Whelan TP, Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurem| | PubMed
  44. The Impact of Hydroxyethyl Starch Use in Deceased Organ Donors on the Development of Delayed Graft Function in Kidney Transplant Recipients: A Propensity-Adjusted Analysis.
    Patel MS, Niemann CU, Sally MB, De La Cruz S, Zatarain J, Ewing T, Crutchfield M, Enestvedt CK, Malinoski DJ| | PubMed
  45. A role for Rac1 activity in malignant progression of sebaceous skin tumors.
    Frances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C| | PubMed
  46. Exercise-induced changes in basal ganglia volume and cognition in older adults.
    Niemann C, Godde B, Staudinger UM, Voelcker-Rehage C| | PubMed
  47. Abdominal transplantation.
    Niemann CU| | PubMed
  48. Patients with chronic kidney disease.
    Kalamas AG, Niemann CU| | PubMed
  49. Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.
    Parekh J, Roll GR, Feng S, Niemann CU, Hirose R| | PubMed
  50. Functional elements associated with hepatic regeneration in living donors after right hepatic lobectomy.
    Everson GT, Hoefs JC, Niemann CU, Olthoff KM, Dupuis R, Lauriski S, Herman A, Milne N, Gillespie BW, Goodrich NP, Everhart JE| | PubMed
  51. Deceased organ donor research: the last research frontier?
    Mone T, Heldens J, Niemann CU| | PubMed
  52. Liver transplantation outcome in patients with angiographically proven coronary artery disease: a multi-institutional study.
    Wray C, Scovotti JC, Tobis J, Niemann CU, Planinsic R, Walia A, Findlay J, Wagener G, Cywinski JB, Markovic D, Hughes C, Humar A, Olmos A, Sierra R, Busuttil R, Steadman RH| | PubMed
  53. Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series.
    Behrends M, Niemann CU, Larson MD| | PubMed
  54. Optimizing cost-effectiveness in perioperative care for liver transplantation: a model for low- to medium-income countries.
    Rando K, Niemann CU, Taura P, Klinck J| | PubMed
  55. Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study.
    Parekh J, Niemann CU, Dang K, Hirose R| | PubMed
  56. Transplant critical care: standards for intensive care of the patient with liver failure before and after transplantation.
    Niemann CU, Kramer DJ| | PubMed
  57. Intraoperative management of liver transplant patients.
    Liu LL, Niemann CU| | PubMed
  58. Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model.
    Martinez-Palli G, Hirose R, Liu T, Xu F, Dang K, Feiner J, Serkova NJ, Niemann CU| | PubMed
  59. Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantation.
    Yong CM, Sharma M, Ochoa V, Abnousi F, Roberts J, Bass NM, Niemann CU, Shiboski S, Prasad M, Tavakol M, Ports TA, Gregoratos G, Yeghiazarians Y, Boyle AJ| | PubMed
  60. Liver transplant perioperative pathways: which way towards high-quality care and better outcomes?
    Biancofiore G, Niemann CU| | PubMed
  61. Mapping the ionization state of laser-irradiated Ar gas jets with multiwavelength monochromatic x-ray imaging.
    Kugland NL, Döppner T, Kemp A, Schaeffer D, Glenzer SH, Niemann C| | PubMed
  62. 1H-NMR-based metabolic signatures of clinical outcomes in trauma patients--beyond lactate and base deficit.
    Cohen MJ, Serkova NJ, Wiener-Kronish J, Pittet JF, Niemann CU| | PubMed
  63. Chronic kidney disease: implications for the perioperative period.
    Eilers H, Liu KD, Gruber A, Niemann CU| | PubMed
  64. Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats.
    Vincenti M, Behrends M, Dang K, Park YH, Hirose R, Blasi-Ibanez A, Liu T, Serkova NJ, Niemann CU| | PubMed
  65. Quality improvement in transplant anesthesia: which way forward?
    Niemann CU, Feiner J| | PubMed
  66. Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines.
    Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ| | PubMed
  67. Evolution of elastic x-ray scattering in laser-shocked warm dense lithium.
    Kugland NL, Gregori G, Bandyopadhyay S, Brenner CM, Brown CR, Constantin C, Glenzer SH, Khattak FY, Kritcher AL, Niemann C, Otten A, Pasley J, Pelka A, Roth M, Spindloe C, Riley D| | PubMed
  68. Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats.
    Behrends M, Martinez-Palli G, Niemann CU, Cohen S, Ramachandran R, Hirose R| | PubMed
  69. Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin.
    Niemann CU, Walia A, Waldman J, Davio M, Roberts JP, Hirose R, Feiner J| | PubMed
  70. Abdominal organ transplantation.
    Niemann CU, Eilers H| | PubMed
  71. Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair.
    Chang CK, Chuter TA, Niemann CU, Shlipak MG, Cohen MJ, Reilly LM, Hiramoto JS| | PubMed
  72. Predictors associated with terminal renal function in deceased organ donors in the intensive care unit.
    Blasi-Ibanez A, Hirose R, Feiner J, Freise C, Stock PG, Roberts JP, Niemann CU| | PubMed
  73. Postoperative infectious complications of abdominal solid organ transplantation.
    Hlava N, Niemann CU, Gropper MA, Melcher ML| | PubMed
  74. High contrast Kr gas jet K alpha x-ray source for high energy density physics experiments.
    Kugland NL, Neumayer P, Döppner T, Chung HK, Constantin CG, Girard F, Glenzer SH, Kemp A, Niemann C| | PubMed
  75. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.
    Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA| | PubMed
  76. Perioperative liver transplant best practices: weighing the evidence.
    Mandell MS, Niemann CU| | PubMed
  77. Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.
    Hirose R, Xu F, Dang K, Liu T, Behrends M, Brakeman PR, Wiener-Kronish J, Niemann CU| | PubMed
  78. Green frequency-doubled laser-beam propagation in high-temperature hohlraum plasmas.
    Niemann C, Berger RL, Divol L, Froula DH, Jones O, Kirkwood RK, Meezan N, Moody JD, Ross J, Sorce C, Suter LJ, Glenzer SH| | PubMed
  79. Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model.
    Park Y, Hirose R, Dang K, Xu F, Behrends M, Tan V, Roberts JP, Niemann CU| | PubMed
  80. A multicenter evaluation of safety of early extubation in liver transplant recipients.
    Mandell MS, Stoner TJ, Barnett R, Shaked A, Bellamy M, Biancofiore G, Niemann C, Walia A, Vater Y, Tran ZV, Kam I| | PubMed
  81. Remote renal injury following partial hepatic ischemia/reperfusion injury in rats.
    Behrends M, Hirose R, Park YH, Tan V, Dang K, Xu F, Park SH, Niemann CU| | PubMed
  82. Biochemical mechanisms of nephrotoxicity: application for metabolomics.
    Niemann CU, Serkova NJ| | PubMed
  83. Early detection of graft failure using the blood metabolic profile of a liver recipient.
    Serkova NJ, Zhang Y, Coatney JL, Hunter L, Wachs ME, Niemann CU, Mandell MS| | PubMed
  84. Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury.
    Fuller TF, Rose F, Singleton KD, Linde Y, Hoff U, Freise CE, Dragun D, Niemann CU| | PubMed
  85. Central venous pressure monitoring during living right donor hepatectomy.
    Niemann CU, Feiner J, Behrends M, Eilers H, Ascher NL, Roberts JP| | PubMed
  86. Ischemia-reperfusion injury is more severe in older versus young rat livers.
    Park Y, Hirose R, Coatney JL, Ferrell L, Behrends M, Roberts JP, Serkova NJ, Niemann CU| | PubMed
  87. Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics.
    Serkova NJ, Niemann CU| | PubMed
  88. Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats.
    Behrends M, Hirose R, Serkova NJ, Coatney JL, Bedolli M, Yardi J, Park YH, Niemann CU| | PubMed
  89. Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.
    Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ| | PubMed
  90. Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores.
    Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R| | PubMed
  91. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats.
    Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU| | PubMed
  92. Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats.
    Noh J, Behrends M, Choi S, Bedolli MA, Yardi J, Hirose R, Niemann CU| | PubMed
  93. Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers.
    Niemann CU, Hirose R, Liu T, Behrends M, Brown JL, Kominsky DF, Roberts JP, Serkova N| | PubMed
  94. Metabolic profiling of livers and blood from obese Zucker rats.
    Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU| | PubMed
  95. H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants.
    Serkova N, Fuller TF, Klawitter J, Freise CE, Niemann CU| | PubMed
  96. Mild hypothermia provides significant protection against ischemia/reperfusion injury in livers of obese and lean rats.
    Choi S, Noh J, Hirose R, Ferell L, Bedolli M, Roberts JP, Niemann CU| | PubMed
  97. Ischemic preconditioning improves rat kidney graft function after severe ischemia/reperfusion injury.
    Fuller TF, Freise CE, Feng S, Niemann CU| | PubMed
  98. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.
    Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U| | PubMed
  99. Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution.
    Avram MJ, Krejcie TC, Henthorn TK, Niemann CU| | PubMed
  100. Intraoperative fluid management of living donor versus cadaveric liver transplant recipients.
    Niemann CU, Hirose R, Stock P, Roberts JP, Mandell S, Spencer Yost C| | PubMed
  101. Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts.
    Fuller TF, Serkova N, Niemann CU, Freise CE| | PubMed
  102. Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury.
    Fuller TF, Freise CE, Serkova N, Niemann CU, Olson JL, Feng S| | PubMed
  103. Mechanism of pupillary reflex dilation in awake volunteers and in organ donors.
    Yang LL, Niemann CU, Larson MD| | PubMed
  104. The effects of desflurane and propofol on portosystemic pressure in patients with portal hypertension.
    Mandell MS, Durham J, Kumpe D, Trotter JF, Everson GT, Niemann CU| | PubMed
  105. Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat.
    Serkova N, Klawitter J, Niemann CU| | PubMed
  106. Clinically important drug interactions with intravenous anaesthetics in older patients.
    Eilers H, Niemann C| | PubMed
  107. Intraoperative hemodynamics and liver function in adult-to-adult living liver donors.
    Niemann CU, Roberts JP, Ascher NL, Yost CS| | PubMed
  108. Elimination of indocyanine green in the perioperative evaluation of donor liver function.
    Mandell MS, Wachs M, Niemann CU, Henthorn TK| | PubMed
  109. Cyclosporine can increase isoflurane MAC.
    Niemann CU, Stabernack C, Serkova N, Jacobsen W, Christians U, Eger EI| | PubMed
  110. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.
    Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N| | PubMed
  111. Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients.
    Niemann CU, Yost CS, Mandell S, Henthorn TK| | PubMed
  112. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.
    Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U| | PubMed
  113. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
    Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U| | PubMed
  114. Isoflurane alters the recirculatory pharmacokinetics of physiologic markers.
    Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK| | PubMed
  115. Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol.
    Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ| | PubMed
  116. Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective.
    Henthorn TK, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ| | PubMed
  117. Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water.
    Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ| | PubMed
  118. The effect of halothane on the recirculatory pharmacokinetics of physiologic markers.
    Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK| | PubMed
  119. A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs.
    Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK| | PubMed
  120. Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs.
    Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, Henthorn TK| | PubMed
  121. Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly.
    Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, Avram MJ| | PubMed