University of California San Francisco

Jason W. Smith, MD, FACS

Jason Smith, MD
Jason W.
Smith
MD, FACS

Division Chief & Professor of Surgery
Helen and Charles Schwab Distinguished Professor of Surgery 
Program Director for the Advanced Fellowship in Cardiac Transplantation & MCS
Division of Cardiac Surgery and Lung Transplantation
Department of Surgery, School of Medicine
University of California, San Francisco
Co-Director, Heart and Vascular Center, UCSF Health 
 

Academic Office: 
513 Parnassus Avenue, Suite 309F, Box 0413
San Francisco, CA 94143
Phone: 415-353-8890
Email: [email protected] 
Assistant: [email protected] 

Cardiac Surgery Program
400 Parnassus Avenue, Suite 501, Box 0957
San Francisco, CA, 94143
Tel: 415-353-1606
Fax: 415-353-1312

Heart Transplant Program
400 Parnassus Avenue, Suite 501, Box 0115
San Francisco, CA 94143
Tel: 415-502-4243
Fax: 415-502-0243

Biography

Dr. Jason W. Smith is a cardiac and transplant surgeon who specializes in heart transplantation and the use of mechanical circulatory support, such as artificial heart pumps and left ventricular assist devices. He has expertise in complex cardiac procedures that include mitral valve repair and replacement, aortic valve surgery, transcatheter aortic valve procedures (minimally invasive techniques to replace a failing valve), surgeries to treat the ascending aorta and aortic arch, treatment of endocarditis (infections of the heart's inner lining), operations to correct atrial fibrillation (irregular and often rapid heartbeats), and sternal repair and reconstruction. He also manages extracorporeal membrane oxygenation (ECMO), which supports the heart and lungs by using a machine to oxygenate blood outside of the body. He is the surgical director of UCSF's heart transplantation and mechanical circulatory support programs.

Smith has been active in a national effort to increase access to heart transplantation by improving the use of donor organs. He served as a primary investigator for a nationwide clinical trial on donation after cardiac death.

Smith earned his medical degree from the Stritch School of Medicine at Loyola University Chicago, then completed a residency in general surgery and a fellowship in cardiothoracic surgery at Loyola University Medical Center. He completed a fellowship in heart and lung transplantation at Stanford Medicine. Upon completing his training, he joined the surgical faculty at the University of Washington. Prior to joining UCSF, he served as surgical director of transplant and mechanical circulatory support at the University of Wisconsin – Madison.

Smith serves on the membership and professional standards committee of the national Organ Procurement and Transplantation Network. He frequently makes presentations on issues related to organ transplantation and utilization and belongs to numerous professional and honorary societies. He is a San Francisco native.

Education

Institution Degree Dept or School End Date
Stanford University Hospital and Clinics Heart and Lung Transplant and Mechanical Circulatory Support 06/2012
Loyola University Medical Center Cardiothoracic Surgery 06/2011
Loyola University Medical Center General Surgery 06/2009
Loyola University Medical Center, Burn Shock Trauma Center Research Fellowship 06/2005
Loyola University Medical School MD Medicine 06/2002
Baylor University BA University Scholar 12/1993

Board Certifications

American Board of Thoracic Surgery, Thoracic and Cardiac Surgery

Clinical Expertise

Heart Transplant

Total Artificial Heart support

left ventricular assist devices

minimally invasive LVAD surgery

Acute heart support

Extra Corporeal membrane oxygenator support (ECMO)

aortic valve repair and replacement

transcatheter aortic valve procedures

mitral valve replacement

mitral valve repair

tricuspid valve repair and replacement

endocarditis

ascending aortic aneurysm

aortic arch aneurysm

reoperative heart surgery

atrial fibrillation surgery

cardiac tumors

Clinical Trials

  1. Levothyroxine Supplementation for Heart Transplant Recipients (NCT06428097)
    Related Conditions: Heart Transplant, Transplants| Start Date: | End Date:

Program Affiliations

UCSF Advanced Heart Failure Comprehensive Care Center

UCSF Heart and Vascular Center

In the News

Meet Jason W. Smith, M.D., New Cardiac Surgeon at UCSF
May, 16, 2022 | UCSF Department of Surgery

Research Interests

Organ donor utilization

DCD heart donation

ex-vivo heart perfusion

normothermic regional perfusion

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 57
  1. A Leg Up: Evaluating Ultramassive Transfusion after Extremity Vascular Injury.
    Grady ZJ, Harfouche MN, Greiffenstein P, Inaba K, Filiberto DM, Meizoso JP, Smith JW, Jacovides CL, McNickle AG, Choron RL, Ross SW, Smith RN, PRODUCT Consortium| | PubMed
  2. Making the case for value of acute care surgery: American Association for the Surgery of Trauma panel on overcoming local challenges.
    Kim P, Murphy P, Kelly E, Haddad DN, Martin RS, Spain DA, Smith JW, Savage SA, Staudenmayer KL| | PubMed
  3. Filling the tank: A multicenter investigation of trauma survival after ultramassive transfusion.
    Grady ZJ, Nguyen J, Meyer CH, Moran TP, Rowh M, Zhang A, Harfouche MN, Greiffenstein P, Trinh S, Inaba K, Nekooei N, Filiberto DM, Jones Sayyid CE, Gutierrez A, Meizoso JP, Risinger WB, Smith JW, Jacovides CL, Trausch ED, McNickle AG, Kumar A, Choron RL, Ross SW, Sanderfer VC, Sciarretta J, Smith RN| | PubMed
  4. Nebulized Heparin and N-Acetylcysteine do Not Improve Outcomes of Intubated Burn Patients With Grade II or III Inhalation Injuries.
    Risinger WB, Hammond VR, Uma CV, Sims BL, Keeven DD, Dye CN, Franklin GA, Smith JW, Miller KR, Benns MV, Nash NA, Pera SJ, Marshall GR, Coleman JC, Harbrecht BG, Bozeman MC| | PubMed
  5. Plasma resuscitation restores glomerular hyaluronic acid and mitigates hemorrhage-induced glomerular dysfunction.
    Risinger WB, Matheson PJ, Franklin ME, Lakshmanan J, Li Y, Harbrecht BG, Smith JW| | PubMed
  6. A response to Henderson et al.'s commentary on Smith and Mayo (2024).
    Smith JW, Mayo A| | PubMed
  7. PLASMA UTILIZATION EXACERBATES RENAL CORTEX INFLAMMATION IN A RODENT MODEL OF HEMORRHAGIC SHOCK AND RESUSCITATION.
    Risinger WB, Matheson PJ, Franklin ME, Hammond VR, Lakshmanan J, Pushpakumar S, Li Y, Volk EE, Harbrecht BG, Smith JW| | PubMed
  8. Beyond Glasgow Coma Scale: Prehospital prediction of traumatic brain injury.
    Schucht JE, Rakhit S, Smith MC, Han JH, Brown JB, Grigorian A, Gondek SP, Smith JW, Patel MB, Maiga AW| | PubMed
  9. Structural racism: A concept analysis.
    Smith JW, Mayo A| | PubMed
  10. Distance to Burn Center Does Not Impact Long-term Anxiety and Depression Risk Following Burn Injury.
    Risinger WB, Dye CN, Thompson SK, Uma CV, Keeven DD, Nash NA, Smith JW, Bozeman MC| | PubMed
  11. Six Square Miles of Urban America: Association Between Firearm Discharge, Injury, and Fatality.
    Risinger WB, Uma CV, Benns MV, Ruther MH, Nash NA, Bozeman MC, Coleman JJ, Smith JW, Harbrecht BG, Miller KR| | PubMed
  12. Phase I clinical trial of the feasibility and safety of direct peritoneal resuscitation in liver transplantation.
    Rodriguez IE, Asher ZP, Klingenberg K, Wright FL, Nydam TL, Adams MA, Bababekov YJ, Peltz E, Smith JW, Saben JL, Kennealey P, Pomposelli JJ, Pomfret EA, Moore HB| | PubMed
  13. Coagulopathy in Penetrating Ballistic Cranial Trauma: A 7-Year Experience.
    Alhourani A, Stephenson TL, Bridwell EM, Danehower SE, Walek KW, Smith JW, Sieg E| | PubMed
  14. 2024 EAST Presidential Address: One Day.
    Smith JW| | PubMed
  15. Not So Vats: How Early Is Too Early in the Operative Management of Patients with Traumatic Hemothorax?
    Uma CV, Risinger WB, Nath S, Pera SJ, Smith JW| | PubMed
  16. Author reply: "What do we mean by source control and what are we trying to accomplish with an open abdomen in severe complicated intra-abdominal sepsis?"
    Risinger WB, Smith JW| | PubMed
  17. Applying the antecedent, behaviour, and consequence taxonomy to unintentional firearm injury as determined by a collaborative firearm injury database.
    Risinger WB, Nickols AK, Harris AN, Benns MV, Nash NA, Bozeman MC, Pera SJ, Coleman JC, Franklin GA, Smith JW, Harbrecht BG, Miller KR| | PubMed
  18. Increasing Utilization of Extended Criteria Donor Hearts for Transplantation: The OCS Heart EXPAND Trial.
    Schroder JN, Patel CB, DeVore AD, Casalinova S, Koomalsingh KJ, Shah AS, Anyanwu AC, D'Alessandro DA, Mudy K, Sun B, Strueber M, Khaghani A, Shudo Y, Esmailian F, Liao K, Pagani FD, Silvestry S, Wang IW, Salerno CT, Absi TS, Madsen JC, Mancini D, Fiedler AG, Milano CA, Smith JW| | PubMed
  19. A Decade of Analysis of Unplanned Extubation Etiology in Trauma Patients Including the Impact of the COVID Pandemic.
    Harbrecht BG, Miller KR, Egger ME, Nash NA, Doan R, Georgel J, Franklin GA, Smith JW, Bozeman MC, Benns MV| | PubMed
  20. Expanding the Donation After Circulatory Death Transplant Pool in the United States.
    Fiedler A, Miller PN, Smith JW| | PubMed
  21. Plasma resuscitation improves and restores intestinal microcirculatory physiology following haemorrhagic shock.
    Schucht JE, Harbrecht BG, Bond LM, Risinger WB, Matheson PJ, Smith JW| | PubMed
  22. Damage control surgery in emergency general surgery: What you need to know.
    Risinger WB, Smith JW| | PubMed
  23. Establishing a core outcome set for blunt cerebrovascular injury: an EAST modified Delphi method consensus study.
    Ziesmann M, Byerly S, Yeh DD, Boltz M, Gelbard R, Haut ER, Smith JW, Stein DM, Zarzaur BL, Bensard DD, Biffl WL, Boyd A, Brommeland T, Cothren Burlew C, Fabian T, Lauerman M, Leichtle S, Moore EE, Timmons S, Vogt K, Nahmias J| | PubMed
  24. Transplantation Outcomes with Donor Hearts after Circulatory Death.
    Schroder JN, Patel CB, DeVore AD, Bryner BS, Casalinova S, Shah A, Smith JW, Fiedler AG, Daneshmand M, Silvestry S, Geirsson A, Pretorius V, Joyce DL, Um JY, Esmailian F, Takeda K, Mudy K, Shudo Y, Salerno CT, Pham SM, Goldstein DJ, Philpott J, Dunning J, Lozonschi L, Couper GS, Mallidi HR, Givertz MM, Pham DT, Shaffer AW, Kai M, Quader MA, Absi T, Attia TS, Shukrallah B, Sun BC, Farr M, Mehra MR, Madsen JC, Milano CA, D'Alessandro DA| | PubMed
  25. Comment on: Detection and management of HLA sensitization in candidates for adult heart transplantation.
    Fiedler AG, Klein L, DeMarco T, Kouretas P, Smith JW| | PubMed
  26. Establishing a core outcomes set for massive transfusion: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study.
    Gelbard RB, Nahmias J, Byerly S, Ziesmann M, Stein D, Haut ER, Smith JW, Boltz M, Zarzaur B, Callum J, Cotton BA, Cripps M, Gunter OL, Holcomb JB, Kerby J, Kornblith LZ, Moore EE, Riojas CM, Schreiber M, Sperry JL, Yeh DD| | PubMed
  27. Molecules, Machines, and the Perfusate Milieu: Organ Preservation and Emerging Concepts for Heart Transplant.
    Wisneski A, Smith JW, Nguyen TC, Fiedler AG| | PubMed
  28. Effect of Plasma Resuscitation with Adjunctive Peritoneal Resuscitation on Hepatic Blood Flow and End-Organ Damage after Hemorrhagic Shock.
    Smith JW, Schucht JE, Harbrecht BG, Bond LM, Matheson PJ| | PubMed
  29. Direct Peritoneal Resuscitation for Trauma.
    Pera SJ, Schucht J, Smith JW| | PubMed
  30. A new pandemic and an old epidemic: The impact of COVID-19 and gun violence as measured by years of potential life lost in a US city.
    Risinger WB, Pera SJ, Bhutiani N, Ruther M, Harbrecht BG, Smith JW, Benns MV, Miller KR| | PubMed
  31. Normothermic regional perfusion surgical technique for the procurement of cardiac donors after circulatory death.
    Fiedler AG, DeVries S, Czekajlo C, Smith JW| | PubMed
  32. Unconventional use of total artificial heart in a patient with severe, destructive prosthetic valve endocarditis.
    Johnstad C, Bomareddi S, Hermsen JL, Smith JW, Fiedler AG| | PubMed
  33. Survival after orthotopic heart transplantation in patients with BMI > = 35 with and without diabetes.
    Fiedler AG, Stalter L, Marka N, Dhingra R, Hermsen JL, Smith JW| | PubMed
  34. Left ventricular assist device implantation by bi-thoracotomy technique: A single-center perspective.
    Stoeckl EM, Smith JW, Dhingra R, Fiedler AG| | PubMed
  35. Risk factors and outcomes for delayed kidney graft function in simultaneous heart and kidney transplant recipients: A UNOS/OPTN database analysis.
    Parajuli S, Karim AS, Muth BL, Leverson GE, Yang Q, Dhingra R, Smith JW, Foley DP, Mandelbrot DA| | PubMed
  36. Successful heart transplantation in a patient who recovered from COVID-19.
    Johnstad CM, Murray D, Dhingra R, Smith JW, Fiedler AG| | PubMed
  37. Orthotopic Heart Transplant: How I Teach It.
    Fiedler AG, Hermsen JL, Bommareddi S, Smith JW| | PubMed
  38. Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival.
    Allana SS, Rajput FA, Smith JW, Lozonschi L, Liou JI, Johnson M, Kohmoto T, Dhingra R| | PubMed
  39. 2020 ACC/HFSA/ISHLT Lifelong Learning Statement for Advanced Heart Failure and Transplant Cardiology Specialists: A Report of the ACC Competency Management Committee.
    Writing Committee Members, Yancy CW, Drazner MH, Coffin ST, Cornwell W, Desai S, Erwin JP, Ginwalla M, Harshaw-Ellis KS, Horwich T, Kittleson M, Lala A, Lewsey SC, Marine JE, Martin C, Meehan K, Morrow DA, Schlendorf K, Smith JW, Stevens GR, ACC Competency Management Committee, Arrighi JA, Mendes LA, Adams JE, Brush JE, Dec GW, Denktas A, Fernandes S, Freeman R, Francis SA, Hahn RT, Halperin JL, Housholder-Hughes SD, Khan SS, Klarich K, Lin CH, Marine JE, McPherson JA, Niazi K, Ryan T, Solomon MA, Spicer RL, Tam M, Wang A, Weissman G, Weitz HH, Williams ES| | PubMed
  40. 2020 ACC/HFSA/ISHLT Lifelong Learning Statement for Advanced Heart Failure and Transplant Cardiology Specialists: A Report of the ACC Competency Management Committee.
    Yancy CW, Drazner MH, Coffin ST, Cornwell W, Desai S, Erwin JP, Ginwalla M, Harshaw-Ellis KS, Horwich T, Kittleson M, Lala A, Lewsey SC, Marine JE, Martin CM, Meehan K, Morrow DA, Schlendorf K, Smith JW, Stevens GR| | PubMed
  41. Long-term discontinuation of warfarin in a patient with HeartMate 3 left ventricular assist device without complication.
    Fiedler AG, Hermsen JL, Smith JW, Dhingra R| | PubMed
  42. Small Left Ventricular Size Is an Independent Risk Factor for Ventricular Assist Device Thrombosis.
    Chivukula VK, Beckman JA, Prisco AR, Lin S, Dardas TF, Cheng RK, Farris SD, Smith JW, Mokadam NA, Mahr C, Aliseda A| | PubMed
  43. Left Ventricular Assist Device Inflow Cannula Angle and Thrombosis Risk.
    Chivukula VK, Beckman JA, Prisco AR, Dardas T, Lin S, Smith JW, Mokadam NA, Aliseda A, Mahr C| | PubMed
  44. Dilemmas in Dual Disease: Complexity and Futility in Prosthetic Valve Endocarditis and Substance Use Disorder.
    Kirkpatrick JN, Smith JW| | PubMed
  45. Invited Commentary.
    Smith JW, Mokadam NA| | PubMed
  46. Pulmonary function tests do not predict mortality in patients undergoing continuous-flow left ventricular assist device implantation.
    Bedzra EKS, Dardas TF, Cheng RK, Pal JD, Mahr C, Smith JW, Shively K, Masri SC, Levy WC, Mokadam NA| | PubMed
  47. The Benefit of Donor-Recipient Matching for Patients Undergoing Heart Transplantation.
    Nguyen VP, Mahr C, Mokadam NA, Pal J, Smith JW, Dardas TF| | PubMed
  48. Outflow Graft Obstruction Treated With Transcatheter Management: A Novel Therapy for a New Diagnosis.
    Bhamidipati CM, Pal JD, Jones TK, McCabe JM, Reisman M, Smith JW, Mahr C, Mokadam NA| | PubMed
  49. Successful Repair of Acute Type A Aortic Dissection 15 Years Following Bilateral Lung Transplantation.
    Hermsen JL, Madathil R, Berfield KS, Li K, Smith JW, Mulligan MS| | PubMed
  50. Endovascular Repair for Type A Aortic Dissection After Transcatheter Aortic Valve Replacement With a Medtronic CoreValve.
    Berfield KK, Sweet MP, McCabe JM, Reisman M, Mackensen GB, Mokadam NA, Dean LS, Smith JW| | PubMed
  51. Systematic donor selection review process improves cardiac transplant volumes and outcomes.
    Smith JW, O'Brien KD, Dardas T, Pal JD, Fishbein DP, Levy WC, Mahr C, Masri SC, Cheng RK, Stempien-Otero A, Mokadam NA| | PubMed
  52. Periportal fibrosis without cirrhosis does not affect outcomes after continuous flow ventricular assist device implantation.
    Sargent JE, Dardas TF, Smith JW, Pal JD, Cheng RK, Masri SC, Shively KR, Colyer LM, Mahr C, Mokadam NA| | PubMed
  53. Late Surgical Bleeding Following Total Artificial Heart Implantation.
    Hermsen JL, Smith JW, Pal JD, Mahr C, Masri SC, Dardas TF, Cheng RK, Mokadam NA| | PubMed
  54. Self-administration education and polypharmacy in mechanical circulatory support patients.
    Hermsen JL, Smith JW, Mokadam NA| | PubMed
  55. The influence of (18)flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma.
    Smith JW, Moreira J, Abood G, Aranha GV, Nagda S, Wagner RH, Shoup M| | PubMed
  56. Immunologic responses to critical injury and sepsis.
    Smith JW, Gamelli RL, Jones SB, Shankar R| | PubMed
  57. New perspectives for a new century: implications of pathogen responses for the future of antimicrobial therapy.
    Melstrom KA, Smith JW, Gamelli RL, Shankar R| | PubMed