Biography
In addition to caring for patients, Posselt conducts research on pancreatic islet cell transplantation, a procedure that can allow people with type 1 diabetes to discontinue insulin therapy. He also investigates mechanisms by which a transplant recipient's body rejects or tolerates tissue from a donor who isn't genetically identical, and he studies the metabolic and biochemical consequences of bariatric surgery.
Posselt earned his medical degree and a doctorate in immunology from the University of Pennsylvania. He completed residencies in internal medicine and general surgery as well as a transplant fellowship at UCSF, before joining the staff in 2003.
Posselt is a member of several professional and honorary societies, and has given presentations on transplant issues related to patient care and research. At UCSF, he supervises residents and fellows in transplant services and general surgery.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of Pennsylvania | PhD | Immunology | 1993 |
University of Pennsylvania | M.D. | School of Medicine | 1993 |
University of California, San Francisco | Residency | Internal Medicine |
Board Certifications
- American Board of Internal Medicine, 1996
- American Board of Surgery, 2002
Clinical Expertise
Bariatric Surgery (Laparoscopic and Open)
Bile Duct Injuries
Bile Duct Strictures
Choledochal Cyst Disease
End-Stage Kidney Disease
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Primary Liver Cancer)
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Liver Cysts
Liver Transplantation
Nonalcoholic Fatty Liver Disease
Pancreas Transplantation
Pediatric Liver Transplantation
Pediatric Kidney Transplantation
Portal Hypertension
Islet Cell Transplantation
Autologous Islet Cell Transplantation
Clinical Trials
- Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol (NCT02402439)Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
- Extended Follow-Up After Islet Transplantation in T1D (NCT01369082)Related Conditions: Diabetes, Diabetes Type 1, Islet Transplantation| Start Date: | End Date:
- Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
- Islet Transplantation in Type 1 Diabetes (NCT00434811)Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
- Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
Program Affiliations
Pancreatic Islet Transplantation Program
Bariatric Surgery Center
ABO-Incompatible Kidney Transplant Program
In the News
Grants and Funding
- Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized control | NIH | 2021-07-14 - 2024-05-31 | Role: Co-Principal Investigator
- Treatment of Type I Diabetes by Islet Transplantation into the Gastric Submucosa | NIH | 2014-05-01 - 2021-04-30 | Role: Principal Investigator
- "Advancing Islet Transplant for Type 1 Diabetes Care" | NIH | 2009-09-30 - 2013-07-31 | Role: Principal Investigator
- Effect of Obesity on Long-Term Clinical Outcomes after Kidney Donation | NIH | 2009-09-21 - 2012-06-30 | Role: Principal Investigator
Research Interests
- Transplantation of pancreatic islets as treatment for type 1 diabetes mellitus
- Assessment of long-term clinical outcomes in kidney donors
- Metabolic and biochemical consequences of bariatric surgery
- Clinical outcomes of bariatric surgery in patients with end-stage kidney or liver disease
Publications
- Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling.| | PubMed
- Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women.| | PubMed
- Splenic Vein Thrombosis Following Pancreas Transplantation: Identification of Factors That Support Conservative Management.| | PubMed
- Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.| | PubMed
- Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.| | PubMed
- Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | PubMed
- Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence.| | PubMed
- Purified Human Pancreatic Islets, CIT Culture Media with Lisofylline or Exenatide.| | PubMed
- An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | PubMed
- Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.| | PubMed